Environmental or self-antigens and homotypic interactions cause BCR and Toll-like receptor (TLR) signaling, amplifying the reaction of CLL cells to other indicators with the microenvironment and expanding the activation of anti-apoptotic and proliferation pathways.31,32 Genomic research have determined recurrent mutations in genes regulating tumor mobile-microenvironment interactions,... https://minerl319fov6.vigilwiki.com/user