Substitution at R3 with a halogen or alkoxy group (74f–74i) resulted in a slight rise in cellular potency With all the halide analogs (74g–h) demonstrating highest the potency in the group. Further optimization triggered the invention of 74i–j, with 74k as the most Energetic compound within the series (pIC50 = https://spencerbwncs.tribunablog.com/indazole-alkylation-an-overview-45865199