Environmental or self-antigens and homotypic interactions result in BCR and Toll-like receptor (TLR) signaling, amplifying the response of CLL cells to other signals from the microenvironment and raising the activation of anti-apoptotic and proliferation pathways.31,32 Genomic reports have determined recurrent mutations in genes regulating tumor mobile-microenvironment interactions, w... https://henryp530isz7.answerblogs.com/profile